Deutsch Intern
    Faculty of Food Chemistry

    Dr. Harald Esch

    Dr. rer. nat. Lebensmittelchemie (TH Karlsruhe)

    Kontakt

    Tel.:      +49 931 318 6964

    E-Mail:   harald.esch@uni-wuerzburg.de

    Raum:   02.030

    Publikationen

    Begutachtete Zeitschriftenbeiträge

    Hiltensperger G, Hecht N, Kaiser M, Rybak JC, Hoerst A, Dannenbauer N, Müller-Buschbaum K, Bruhn H, Esch H, Lehmann L, Meinel L, Holzgrabe U. Quinolone Amides as Antitrypanosomal Lead Compounds with In Vivo Activity. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4442-52. doi: 10.1128/AAC.01757-15. Print 2016 Aug.

    Scheffler A, Albrecht A, Esch H, Lehmann L. Data in support of the mutagenic potential of the isoflavone irilone in cultured V79 cells Toxicology Letters 234 (2015), pp. 81-91. doi:10.1016/j.dib.2015.07.010

    Scheffler A, Albrecht A, Esch H, Lehmann L. Mutagenic potential of the isoflavone irilone in cultured V79 cells. Toxicology Letters 234 (2015), pp. 81-91. 10.1016/j.toxlet.2015.02.013

    Pfenning C, Esch HL, Fliege R, Lehmann L. The mycotoxin patulin reacts with DNA bases with and without previous conjugation to GSH: implication for related α,β-unsaturated carbonyl compounds? Arch Toxicol. 2014 Dec 24

    Lutter S, Schmalbach K, Esch HL, Lehmann L. The isoflavone irilone contributes to the estrogenic potential of dietary supplements containing red clover. Arch Toxicol. 2013, DOI: 10.1007/s00204-013-1114-5.

    Lödige M, Lewis MD, Paulsen ES, Esch HL, Pradel G, Lehmann L, Brun R, Bringmann G, Mueller AK. A primaquine-chloroquine hybrid with dual activity against Plasmodium liver and blood stages. Int J Med Microbiol. 2013 Aug 5. doi:pii: S1438-4221(13)00101-X.10.1016/j.ijmm.2013.07.005.

    Lauby-Secretan B, Loomis D, Grosse Y, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Baan R, Mattock H, Straif K; International Agency for Research on Cancer Monograph Working Group IARC, Lyon, France. Collaborators (25):
    Cogliano VJ, Aronson K, Tryphonas H, Guo YL, Machala M, Bonefeld-Jørgensen EC, Vorkamp K, Cravedi JP, Le Bizec B, Narbonne JF, Esch H, Cocco P, Merletti F, Vermeulen R, Agudo A, Johansson N, Fiedler H, Hopf N, Glauert HP, Herbert RA, James MO, Ludewig G, Robertson L, Ruder A, Walker N. Carcinogenicity of polychlorinated biphenyls and polybrominated biphenyls. Lancet Oncol. 2013 Apr;14(4):287-8. doi: 10.1016/S1470-2045(13)70104-9. Epub 2013 Mar 15.

    Jacobus JA, Wang B, Maddox C, Esch H, Lehmann L, Robertson LW, Wang K, Kirby P, Ludewig G (2010). 3-Methylcholanthrene (3-MC) and 4-Chlorobiphenyl (PCB3) genotoxicity is gender-related in Fischer 344 transgenic rats. Environ. Int. 36, 970-979.

    Garcia C, Ball N, Cagen S, Carrillo JC, Certa H, Eigler D, Esch H, Graham C, Haux C, Kreiling R, Mehling A (2010). Comparative testing for the identification of skin-sensitizing potentials of nonionic sugar lipid surfactants. Regul. Toxicol. Pharmacol. 58, 301-307.

    Basketter D, Ball N, Cagen S, Carrillo JC, Certa H, Eigler D, Garcia C, Esch H, Graham C, Haux C, Kreiling R, Mehling A (2009). Application of a weight of evidence approach to assessing discordant sensitisation datasets: implications for REACH. Regul. Toxicol. Pharmacol. 55, 90-96.

    Ludewig G, Lehmann L, Esch H, Robertson LW (2008). Metabolic Activation of PCBs to Carcinogens in Vivo - A Review. Environ. Toxicol. Pharmacol. 25, 241-246.

    Lehmann L, Esch HL, Kirby AP, Robertson LW, Ludewig G (2007). 4-monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats. Carcinogenesis 28, 471-478.

    Lehmann L, Esch HL, Wagner J, Rohnstock L, Metzler M (2005). Estrogenic and genotoxic potential of equol and two hydroxylated metabolites of Daidzein in cultured human Ishikawa cells. Toxicol. Lett. 158, 72-86.

    Buchbeiträge

    Esch HL, Kleider C, Scheffler A, Lehmann L (2016). Isoflavones: Toxicological aspects and efficacy. In: Nutraceuticals: Efficacy, Safety and Toxicity edited by R.C. Gupta. Elsevier, pp. 467-489.

    Ludewig G, Esch H, Robertson LW (2006). Polyhalogenierte Bi- und Terphenyle. In: Handbuch der Lebensmitteltoxikologie. Dunkelberg H, Gebel T, Hartwig A (Hrsg.), Wiley-VCH, Weinheim, 1031-1070.

    Eingeladene Zeitschriftenbeiträge

    Lehmann L, Esch H (2010). Gesundheitsbezogene Angaben zu Lebensmitteln sowie Gehalte, Verfügbarkeit und Wirksamkeit von Polyphenolen. Nachrichten aus der Chemie 58, 339-344.

    Kongressbeiträge

    Esch HL, Pfeiffer E, Metzler M, Lehmann L (2010). Formation of mixed adducts with glutathion and adenine: a possible contribution to the mutagenicity of the mycotoxin patulin. The Toxicologist, 114, 310. Diskussionsbeitrag. 49. Jahrestagung der Society of Toxicology, 07.-11.03.2010, Salt Lake City, Utah, USA.

    Carrillo J-C, Stuart C, Haux C, Ball N, Certa H, Eigler D, Garcia C, Graham C, Kreiling R, Mehling A, Esch H (2009). Surfactants: Inconsistent results between the LLNA and guinea pig sensitization tests. Toxicol. Lett. 189, S269. Posterbeitrag. 46. Kongress der European Societies of Toxicology, 13-16.09.2009, Dresden, Germany.

    Garcia C, Ball N, Cagen S, Carrillo J-C, Certa H, Eigler D, Esch H, Graham C, Haux C, Kreiling R, Mehling A (2009). Comparison of LLNA and GPMT results for the identification of skin sensitizing potentials of the category of non-ionic sugarlipid surfactants. Toxicol. Lett. 189, S268. Posterbeitrag. 46. Kongress der European Societies of Toxicology, 13-16.09.2009, Dresden, Germany.

    Basketter D, Ball N, Cagen S, Carrillo J-C, Certa H, Eigler D, Esch H, Garcia C, Graham C, Haux C, Kreiling R, Mehling A (2009). Analysing discordant local lymph node assay datasets: Implications for REACH. Toxicol. Lett. 189, S267. Posterbeitrag. 46. Kongress der European Societies of Toxicology, 13-16.09.2009, Dresden, Germany.

    Jacobus J, Lehmann L, Esch HL, Robertson LW, Ludewig G (2007). Assessment of 4-chlorobiphenyl in vivo using the Big Blue rat model: mutagenicity, gene expression, and histology. The Toxicologist 86, 158. Posterbeitrag. 46. Jahrestagung Society of Toxicology, 25.-29.03.2007, Charlotte, North Carolina, USA.

    Lehmann L, Flor S, Zettner M, Esch HL, Robertson LW, Ludewig G (2006). Mutagenicity of 4-monochlorobiphenyl and its metabolites in vitro and in vivo. Drug Metab. Rev. 38 (S3), 163. Posterbeitrag. 14th North American ISSX Meeting, 22. - 26.10.2006, Rio Grande, Puerto Rico.

    Esch HL, Lehmann L, Robertson LW, Ludewig G (2006). 4-Monochlorobiphenyl is mutagenic in the liver of transgenic BigBlue® rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 372, 106. Posterbeitrag. 47. Frühjahrstagung der Deutschen Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie (DGPT), 04.-06.04.2006, Mainz, Deutschland.

    Jacobus J, Lehmann L, Esch HL, Robertson LW, Ludewig G (2006). Detection of DNA base mutations in vivo after exposure to 4-chlorobiphenyl (PCB3) using the Big Blue rat model. Posterbeitrag. Superfund Basic Research Program Annual Meeting, 11.-12.12.2006, San Diego, California, USA. Best student poster award (Biomedical) an J. Jacobus.

    Jacobus J, Lehmann L, Esch HL, Robertson LW, Ludewig G (2006). The transgenic Big Blue rat – A model system to analyze the in vivo mutagenicity of PCBs. Posterbeitrag. 4th PCB Workshop: Recent Advances in the Environmental Toxicology and Health Effects of PCBs, 06.-10.09.2006, Zakopane, Polen.

    Esch HL, Ludewig G (2005). PBDEs or PCBs with perfluorinated compounds: synergy in the induction of Se-glutathione peroxidase, cell cycle arrest and cytotoxicity in human HepG2 cells. Mutat. Res. 577S. Posterbeitrag. 9th International Conference on Environmental Mutagens/36th Annual Meeting of the Environmental Mutagen Society, 03.-08.09.2005 San Francisco, California, USA.

    Esch HL, Robertson LW, Ludewig G (2005). Mixture effects of PCBs and PBDEs with other contaminants/drugs. The Toxicologist 84, 421. Posterbeitrag. 44. Jahrestagung der Society of Toxicology, 06.-10.03.2005, New Orleans, Louisiana, USA.

    Pfeiffer E, Esch HL; Hoehle S, Solyom AM, Timmermann BN, Metzler M (2004). In vitro studies on the estrogenic activity and the metabolism of curcumin. Functional Food: Safety Aspects, 325-329. Posterbeitrag. Symposium der DFG Senatskommission zur Beurteilung der gesundheitlichen Unbedenklichkeit von Lebensmitteln, 05.-07.05.2002, Karlsruhe, Deutschland. 

    Lehmann L, Förster R, Esch HL, Metzler M (2004). Studies on the estrogenic and genotoxic potential of equol and two hydroxylated daidzein metabolites in cultured Ishikawa cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 369, R115. Posterbeitrag 45. Frühjahrstagung der Deutschen Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie (DGPT), 09.-11.03.2004, Mainz, Deutschland.

    Esch HL, Pfeiffer E, Metzler M (2003). Estrogenic and antiestrogenic properties of bisphenol A and related bisphenols in Ishikawa cells. The Toxicologist 72, 134-135. Posterbeitrag. 42. Jahrestagung der Society of Toxicology, 09.-13.03.203, Salt Lake City, Utah, USA.

    Lehmann L, Esch HL, Metzler M (2003). Transcription and activation of estrogen target genes: reliable quantification by competitive reverse transcription/polymerase chain reaction. Posterbeitrag. 4th Karlsruhe Nutrition Symposium, 08.-11.10.2003, Karlsruhe, Deutschland.

    Pfeiffer E, Esch HL, Höhle S, Metzler M, Solyom AM, Timmermann BN (2002). Chemical stability of curcuminoids and their estrogenic activity in Ishikawa cells. The Toxicologist 66, LB 112. Posterbeitrag. 41. jahrestagung der Society of Toxicology, 09.-13.03.2002, USA.

    Esch HL, Newill I, Pfeiffer E, Metzler M (2002). Estrogenic activity assessment of xenoestrogens based on the stimulation of alkaline phosphatase in Ishikawa cells. Naunyn-Schmiedeberg‘s Arch. Pharmacol. 365 (S1), R155. Posterbeitrag. 43. Frühjahrstagung der Deutschen Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie (DGPT), 12.-14.03.2002, Mainz, Deutschland.

    Esch HL, Newill I, Pfeiffer E, Metzler M (2001). Estrogenic activity assessment of xenoestrogens based on the stimulation of alkaline phosphatase in Ishikawa cells. Posterbeitrag. 9. Gordon Research Conference on Hormonal Carcinogenesis, 08.-13.07.2001, Meriden, Maine, USA.

    Lehrtätigkeiten

    Semesterbetreuer

    Master Studiengang LMC Fachsemster 4

    Vorlesungen/Seminare

    Vorlesungen Lebensmitteltoxikologie I und II (Teil des Moduls "Lebensmitteltoxikologie", Master LMC)

    Vorlesung Warenkunde, Chemie und Analytik der Tabakerzeugnisse und Bedarfsgegenstände (Teil des Moduls "Warenkunde, Chemie und Analytik der kosmetischen Mittel, der Bedarfsgegenstände und der Tabakerzeugnisse", Master LMC)

    Vorlesungen Umweltchemie und -toxikologie und Umweltanalytische Methoden (Teil des Moduls "Umweltanalytik", Master LMC)

    Betreute Praktika

    Praktikum Angewandte Biochemie einschließlich Ernährungslehre 2 (Teil des Moduls "Praktikum: Angewandte Biochemie einschließlich Ernährungslehre", Master LMC)

    Praktikum Lebensmitteltoxikologie (Teil des Moduls "Lebensmitteltoxikologie", Master LMC)

    zum Vorlesungsverzeichnis

    zu WueCampus

    Contact

    Lehrstuhl für Lebensmittelchemie
    Am Hubland
    97074 Würzburg

    Phone: +49 931 31-85480
    Fax: +49 931 31-85484
    Email

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    Hubland Süd, Geb. C7